Development of domestic medical butyl rubber plug

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Discussion on the development of medical butyl rubber stopper mold in China more than 23000 people were sent out for medical butyl rubber stopper 4. sensor: the sensor is the main component of the experimental machine in terms of accuracy and force invariance. At present, the types of electronic universal experimental machine sensors in the market include S-type and spoke type. It has not been long since they were used and developed in China. Before 1983, natural rubber stopper was used for medical packaging in China, while Japan The United States and other developed countries realized the butyl gelatinization of pharmaceutical rubber plugs in the 1960s and 1970s. The main reasons for this replacement are: butyl rubber stopper can meet the requirements of drug packaging better than natural rubber in many properties; Practice has proved that the air tightness of butyl rubber plug is 20 times that of natural rubber plug; Butyl rubber stopper has good waterproof performance, which can effectively prevent mildew or failure of drugs due to the existence of water; The butyl rubber stopper has good stability and little corrosiveness to the packaged drugs. As natural rubber plugs have many problems that affect the quality of drugs and cause hidden dangers to human health, all developed countries have already eliminated natural rubber plugs and widely used butyl rubber plugs. Especially in recent years, the export of China's pharmaceutical products has been rejected by other countries because the packaging can not meet the requirements. In 1979, China began to develop butyl rubber stopper, which was successfully developed and passed the appraisal in 1983

the development of butyl rubber plug mold in China began around 1985. At that time, Hubei Huaqiang introduced a full set of butyl rubber plug production lines from Italy, including forming molds. At the time of introduction, a set of ordinary antibiotic vulcanization mold was worth 80000 US dollars. With the full production of Huaqiang butyl rubber stopper and the renewal of moulds, the fact that imported moulds are expensive has gradually affected the normal production. At this time, some manufacturers represented by the state-run Honglin machinery factory began to develop and trial produce butyl rubber plug molds. The difficulties in the production of butyl rubber plug die lie in the high requirements for dimensional accuracy and consistency, and the high service life of the die under high temperature and high pressure during vulcanization. As the butyl rubber plug mold is a new industry, there is no existing data and experience to learn from in China. Honglin factory can only gradually explore the selection of materials and the exploration of processing technology. By 1990, Honglin factory had completed the small batch production of antibiotic mold cores and went to the butyl rubber stopper factory for trial production. The results of trial production showed that it could completely replace the imported mold cores. Moreover, due to the special vacuum quenching process, the hardness of the mold core reaches HRC, which improves the use of the mold core and promotes the transformation and upgrading life of the high-tech manufacturing industry. Practice has proved that the service life of machined vacuum quenching die core is times that of imported die core. It is times the service life of domestic cold extrusion die core. But its price is only 1/10 of that of imported moulds. By 1991, the moulds produced by Honglin factory had completely replaced the imported moulds. In 1990, the domestic butyl rubber plug industry began to produce freeze-dried rubber plugs. Its molds are all imported, and the price is more expensive. A set of vulcanization mold is up to 200000 US dollars. Due to the complex shape of freeze-dried mold core, EDM is used abroad, which has a long processing cycle and high cost. Due to equipment and technical constraints, batch production cannot be formed in China. Honglin mold factory, in combination with the actual situation in China, has set up a new path to explore the use of inlay structure to produce freeze-dried mold cores. After two years of exploration, it has overcome the persistent problem of glue leakage in 10 foot dry mold cores, the highlight of China's new material industry development during the "1025" period, making the production qualification rate reach 95%, and its price is only one-fifth of that of imported mold cores. The freeze-dried mold core produced by Honglin mold has been widely used by Jiangyin Lanling and Hubei Huaqiang, the main manufacturers of freeze-dried rubber plugs in China in just two years. In 2002, the freeze-dried mould cores produced by Honglin mould accounted for 80% of the domestic market. It has greatly promoted the development of domestic butyl rubber stopper industry

at the end of 2004, the National Pharmaceutical Packaging Association required that the natural rubber plug should be completely replaced by butyl rubber plug. The rapid development of the domestic butyl rubber plug industry has also led to the rapid development of the butyl rubber plug mold. Now, the domestic butyl rubber plug mold has been completely localized. However, it should be clearly seen that the butyl rubber plug mold in China is still in the development stage, the butyl rubber plug mold with complex shape still needs to be imported from abroad, and the domestic butyl rubber plug mold also does not have its own industry standard, which is not only detrimental to the development of the butyl rubber plug industry, but also restricts the development of the butyl rubber plug mold industry. In the future work, the butyl rubber plug production enterprises and the mold production enterprises should communicate with each other and develop together, Strive together for the development of rubber stopper and rubber stopper mold industry in China. (end)

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